Biochemistry Journal – Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats.

Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.
Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups (A-E). Rats in group A (negative control) were orally administered, once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B, C, D, and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone (group B, reference drug), 250, 500 and 1 000 mg/kg body weight of the extract respectively (groups C-E).

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